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ELCC主席说丨周彩存教授和Ruffini教授深度解读:肺癌治疗的热点与争议

作者:肿瘤瞭望   日期:2025/4/18 11:14:12  浏览量:1646

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在2025年欧洲肺癌大会(ELCC)上,国际肺癌研究协会(IASLC)候任主席、上海市东方医院肿瘤科周彩存教授与2025 ELCC联合主席、意大利都灵大学胸外科Enrico Ruffini教授展开深度对话,讨论了新辅助化疗联合免疫治疗与微创手术的整合、围手术期免疫治疗患者选择、辅助治疗时长优化、降阶梯策略等议题,揭示了多学科协作下的治疗新范式。

肿瘤瞭望:2025 ELCC讨论了“生活质量明确恶化时间(TTDD)是否应成为早期NSCLC免疫治疗的新关键终点”,请两位专家针对这一话题分享思考。

周教授:在临床实践中,若新疗法无法改善患者的生活质量,则不应被常规采纳。我们应给予患者报告结局(PRO)更多关注,因为生活质量对患者来说很重要。
 
Ruffini教授:我完全赞同。在浏览2025 ELCC壁报时,我发现一些研究探索了生活质量指标这个关键议题。我们现已建立完善的评估体系来衡量生活质量,这正是"以患者为中心"医疗理念的核心要义——让患者成为治疗的中心焦点。若真正践行这一理念,就意味着必须将生活质量纳入关键考量维度。如果一种方案“治愈”患者却同时摧毁其生活质量,那么这种治疗毫无价值,我们必须在疗效与生存质量之间取得平衡。
 
Dr.Zhou:That’s a great question.How we treat our patients should improve quality of life.If a new therapy does not improve quality of life,it is not acceptable in our daily practice.Quality of life is very important.We should pay more attention to patient-reported outcomes.
 
Dr.Ruffini:Yes,I cannot agree more.I had a look at the posters,for example,and some posters addressed this very important issue–quality of life.We have metrics to measure quality of life.This is part of what we call patient-centered medicine–to put the patient at the center of our cure.If we want to put the patient at the center of our treatment process,this means also taking into account the quality of life.In my opinion,it is completely worthless to cure a patient,but at the same time,destroy the patient–to reduce the patient to a very poor quality of life,psychologically or functionally.We need to provide a balance in that regard.For this reason,I think your question is very pertinent.
 
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